NAME OF THE PROJECT
Mechanisms of initiation of the Ewing sarcoma: signs of cellular propagation
DATES
october 2008-october 2011
PLACE
Centro de Investigación del Cáncer de Salamanca
PERSON RESPONSIBLE
Dr. Enrique de Alava
INVESTIGATION TEAM
Ana Pastora Otero
Ana Sofía Martins
Ana Teresa Amaral
Carlos Mackintosh
Daniel Osuna
David Herrero
Gemma Caballero
José Luis Ordóñez
Victoria Sevillano
HYPOTHESIS OF THE PROJECT
The transfection of the mesenchymal stem cells with EWS-FLi1, the characteristic gene fusion of the Ewing sarcoma (ES) is not enough to induce a full tumourgenicity. There must be other factors that act before or after the presence of translocation in the cells of origin, and that explain the appearance of the ES. It is possible that these factors are also related to the determination of the resistance of some ES to conventional therapies.
TARGET OF THE PROJECT
1. Study of the molecular events prior to the translocation in the Ewing sarcoma.
2. Characterisation of the lines of human mesenchymal stem cells of donor/patient, transfected with a inducible model of the translocation.
3. Identification of the propagation of stem cells of ES and of the marked characteristic.
AVAILABLE FUNDS
Total budget: 100.390,00€